Henan Traditional Chinese Medicine

Current Issue

  • Application of Zhang Zhongjing's Thought of "Supporting Yang and Calming the Spirit" in Insomnia

    ZHANG Yong;QIAN Renyi;MA Yunzhi;ZHU Shirui;LAN Rui;The Third Affiliated Hospital of Zhengzhou University;The First Affiliated Hospital of Henan University of Chinese Medicine;

    According to Zhang Zhongjing's thought of " supporting yang and calming the spirit," " supporting yang" focuses on warming and invigorating the declining yang qi in the human body to address the root cause,while " calming the spirit" aims to stabilize and anchor the floating and scattered mental activities to alleviate the symptoms,ultimately achieving the state where " yang qi returns to its proper position and the spirit is stored. " Insomnia may primarily result from yang deficiency,or it may result from excess pathogens such as phlegm-fluid retention or blood stasis obstructing yang qi circulation. The former should be treated mainly with warming and tonifying methods,while the latter requires eliminating pathogens first,accompanied by supporting yang. For the syndrome of lesser yin meridians' yang deficiency with unrestrained floating spirit,the pathogenesis involves the decline of heart and kidney yang qi in the lesser yin meridians,leading to unclear sovereign fire,inability to warm the heart spirit,and failure to absorb yang into yin,resulting in malnourishment of the heart spirit and imbalance between yin and yang. Treatment should focus on warming and nourishing lesser yin with formulas such as True Warrior Decoction; Cinnamon Twig Decoction Plus Dragon Bones and Oyster Shell to strengthen the source of fire and invigorate the heart spirit. For the syndrome of middle energizer deficiency-cold with malnourished spirit,the pathogenesis involves dietary irregularities and excessive consumption of raw or cold foods,leading to impaired spleen yang and deficiency-cold in the middle energizer. Treatment should focus on warming and fortifying the middle energizer with formulas such as Center-Regulating Decoction,Astragalus Center-Fortifying Decoction to restore its pivoting function and harmonize the nutrient and defense qi. For the syndrome of floating yang due to deficiency,the pathogenesis involves deficiency of both yin and yang,where yang loses its consolidating function and yin fails to retain internally,causing deficient yang to float upward instead of anchoring to yin fluid. Treatment should focus on subduing and anchoring the floating yang with formulas such as Bupleurum Decoction Plus Dragon Bones and Oyster Shell to harmonize yin and yang,calm the mind and stabilize consolidation and astringency. For the syndrome of constrained yang failing to reach with restless spirit,the pathogenesis lies not in insufficiency of yang qi but in stagnation along its pathway,representing a functional disorder. Treatment should focus not on warming and tonifying,but on dispersing and unblocking the constrained yang,using formulas such as Frigid Extremities Powder,Bupleurum Decoction Plus Dragon Bones and Oyster Shell to promote yang circulation and guide yang into yin. For the syndrome of yin deficiency with floating yang and unsettled spirit,the pathogenesis involves exhaustion of true yin,where yin fails to support yang. The heat manifestations are due to deficient fire,not excess heat. Treatment should focus on nourishing yin and subduing floating yang with formulas like Coptis and Donkey-Hide Gelatin Decoction,using thick,flavorful substances to nourish and establish the strong foundation,and bitter-cold drugs to clear and settle the floating yang.

    2026 03 v.46;No.411 [Abstract][OnlineView][Download 146K]

  • Clinical Study on Minor Green Dragon Decoctio Combined with Two Matured Substances Decoction in the Treatment of Bronchopneumonia in Children with Wind-Cold Obstructing the Lung Syndrome

    LI Yuan;SUN Mingying;The Fifth Chinical Medical School of Henan University of Chinese Medicine,Zhengzhou People's Hospital;

    Objective: To investigate the clinical efficacy of Minor Green Dragon Decoction combined with Two Matured Substances Decoction on bronchopneumonia in children with wind-cold obstructing the lung syndrome. Methods: A total of 136 children with bronchopneumonia were randomly divided into the control group and the study group using the random number table method,with 68 cases in each group. The control group received conventional Western medicine treatment,while the study group received Minor Green Dragon Decoction combined with Two Matured Substances Decoction in addition to the control group's treatment. The clinical efficacy,symptom improvement time,changes in TCM syndrome scores,blood gas analysis indicators [including partial pressure of oxygen( Pa O_2),partial pressure of carbon dioxide( Pa CO_2),and oxygen index( Oi) ],and levels of inflammatory factors [C-reactive protein( CRP),procalcitonin( PCT),and tumor necrosis factor-α( TNF-α) ] before and after treatment were compared between the two groups. Results: The effective rate in the study group was 91. 18%,which was higher than 76. 47% in the control group,with a statistically significant difference( P < 0. 05). After treatment,the TCM syndrome scores for fever,cough,pulmonary moist rales,shortness of breath,and excessive yellow sputum,etc. were lower than those before treatment in the two groups,and the above scores in the study group were lower than those in the control group,with statistically significant differences( P < 0. 05). Pa O_2 and Oi were higher,while Pa CO_2 was lower than that before treatment in the two groups,with statistically significant differences( P < 0. 05). The levels of CRP,PCT,and TNF-α in the two groups were all lower than those before treatment,and the above levels in the study group were lower than those in the control group,with statistically significant differences( P < 0. 05). The improvement times for symptoms such as fever,cough,and shortness of breath in the study group were shorter than those in the control group,with statistically significant differences( P < 0. 05). Conclusion:Minor Green Dragon Decoction combined with Two Matured Substances Decoction demonstrates significant efficacy in treating bronchopneumonia in children with wind-cold obstructing the lung syndrome. It not only improves clinical symptoms and promotes respiratory function recovery,but also effectively inhibits the inflammatory response in the body.

    2026 03 v.46;No.411 [Abstract][OnlineView][Download 159K]

  • Efficacy Observation of Modified Frigid Extremities Powder Combined with Gallbladder-Warming Decoction in Treating Bile Reflux Gastritis with Liver-Stomach Disharmony Syndrome

    WANG Fei;ZHAO Lei;XU Jiaojiao;ZHU Yanjie;HOU Liufa;Henan Integrative Medicine Hospital;

    Objective: To observe the clinical efficacy of Modified Frigid Extremities Powder combined with Gallbladder-Warming Decoction on bile reflux gastritis( BRG) with liver-stomach disharmony syndrome. Methods: A total BRG 92 patients with liver-stomach disharmony syndrme admitted to Henan Integrative Medicine Hospital from January 2022 to December 2024 were selected as the study subjects,and divided into the control group and the observation group using the random number table method,with 46 cases in each group.The control group received conventional Western medicine treatment,while the observation group received Modified Frigid Extremities Powder combined with Gallbladder-Warming Decoction on the basis of the treatment given to the control group. The clinical efficacy,incidence of adverse reactions,recurrence rate,changes in TCM syndrome scores,quality of life scores,and serum gastrointestinal hormone levels [including motilin( MTL),growth hormone( GH),gastrin( GAS),cholecystokinin( CCK) ] before and after treatment were compared between the two groups. Results: The effective rate in the observation group was 97. 83%,which was higher than 76. 09% in the control group,and the difference was statistically significant( P < 0. 05). After treatment,scores for epigastric distension and pain,belching and acid regurgitation,nausea and vomiting,bitter taste and dry throat,poor appetite,and hypochondriac distension in the two groups were all lower than those before treatment within each group; furthermore,the scores in the observation group were lower than those in the control group after treatment,with statistically significant differences( P < 0. 05). Scores for daily function,psychological and emotional status,impact on social interaction,reflux,defecation,and dyspepsia in the two groups were significantly lower than those in the control group,with statistically significant differences( P < 0. 05). Serum levels of MTL and GAS in the two groups were higher than those before treatment within each group,while CCK levels were lower; furthermore,there were statistically significant differences between the two groups( P < 0. 05). The incidence of adverse reactions in the observation group was 8. 70%,lower than 28. 26% in the control group,with a statistically significant difference( P < 0. 05). The recurrence rate was 6. 52% in the observation group,which was lower than 19. 57% in the control group,with a statistically significant difference( P < 0. 05). Conclusion: Modified Frigid Extremities Powder combined with Gallbladder-Warming Decoction demonstrates significant efficacy in treating BRG with liver-stomach disharmony syndrome. It can effectively alleviate patients' symptoms,improve their quality of life,and regulate gastrointestinal hormone levels.

    2026 03 v.46;No.411 [Abstract][OnlineView][Download 167K]

  • The Effect of Supplemented Frigid Extremities Decoction Combined with Progesterone Injection on Inflammatory Factors and Endometrium in Patients with Endometriosis

    MA Yan;MAI Weihong;Zhoukou People's Hospital;

    Objective: To observe the effect of Supplemented Frigid Extremities Decoction combined with Progesterone Injection on inflammatory factors and endometrium in patients with endometriosis. Methods: A total of 126 patients with endometriosis were selected as the study subjects and randomly divided into the group of Frigid Extremities Decoction and the progesterone group using the random number table method,with 63 cases in each group. The progesterone group received intramuscular injection of Progesterone,while the group of Frigid Extremities Decoction S received Supplemented Frigid Extremities Decoction in addition to the treatment administered to the progesterone group. Changes in the levels of inflammatory factors [including tumor necrosis factor( TNF)-αand interleukin( IL)-6,IL-8],endometrium before and after treatment and clinical efficacy were observed in the two groups. Results: The effective rate was93. 65% in the group of Frigid Extremities Decoction,which was higher than 77. 78% in the progesterone group,with a statistically significant difference( P < 0. 05). After treatment,the TCM syndrome scores in the group of Frigid Extremities Decoction were lower than those in the progesterone group,with statistically significant differences( P < 0. 05). Additionally,the levels of TNF-α,IL-6,and IL-8 in the group of Frigid Extremities Decoction were significantly lower than those in the progesterone group,endometrial thickness were significantly higher than those in the progesterone group,with statistically significant differences( P < 0. 05). Conclusion: Supplemented Frigid Extremities Decoction combined with Progesterone Injection demonstrates significant clinical efficacy in treating endometriosis. It can reduce the levels of inflammatory factors and improve endometrial thickness in patients with endometriosis.

    2026 03 v.46;No.411 [Abstract][OnlineView][Download 148K]

  • Treatment of Palpitations Based on the Theory of "Sufficiency and Density of Yang Ensuring Harmony and Peace"

    LI Jia;WENG Jinlong;Fujian University of Traditional Chinese Medicine;The People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine;

    The core pathogenesis of palpitations lies in the failure of the yang qi of the five zang organs to remain dense and secure,allowing yin pathogens such as phlegm-fluid retention and blood stasis to invade when deficiency arises. The root is deficiency of heart yang,while the manifestation is internal stagnation of yin pathogens. Treatment should employ a combined approach of " unblocking and reinforcing. " On the one hand,emphasis should be placed on " reinforcing," supplementing the deficiency of heart yang to support cardiac weakness; on the other hand,attention should also be given to " unblocking," eliminating excess yin pathogens to dredge heart yang. For deficiency of heart yang,warming and tonifying heart yang is indicated,with Cinnamon Twig and Licorice Decoction as the basic formula. When heart spirit floats outward and irritability gradually emerges,substances such as Longgu( Os Draconis) and Muli( Concha Ostreae) are added to calm the heart and tranquilize the spirit. When yang damage affects yin,resulting in dual deficiency of yin and yang,Honey-Fried Licorice Decoction can be used to mutually support yin and yang. When harmony is restored,palpitations then naturally cease. For dual deficiency of the heart and spleen,Minor Center-Fortifying Decoction can be adopted. When palpitations arise from yin pathogens obstructing heart yang,not only should heart yang be stimulated to expel the pathogens outward,but the root should also be addressed by treating other zang organs to eliminate the source of pathogen generation. If fluid pathogens accumulate in the upper energizer and obstruct the qi movement,Pinellia and Ephedra Pills can be used to disseminate and descend lung qi,unblock yang,and disperse retained fluid. For spleen yang deficiency,Modified Poria and Cinnamon Twig and Atractylodes Macrocephala and Licorice Decoction,Aconite Middle-Regulating Decoction are used to warm yang and tonify the earth. For kidney yang deficiency,True Warrior Decoction is adopted to warm the kidney and assist yang. For liver depression with blood stasis,Bupleurum Liver-Soothing Powder,and Frigid Extremities Powder are used to soothe the liver and regulate qi,as well as promoting blood circulation and removing blood stasis. When wind-cold causes lung constraint and failure of diffusion,Mahuang( Herba Ephedrae) and Jingjie( Herba Schizonepetae) are used to acridly disperse pathogens,while Zisu( Folium et Caulis Perillae) and Xingren( Semen Armeniacae Amarum) are employed to diffuse the lung and regulate qi. When wind-heat causes lung constraint and failure of diffusion,Jinyinhua( Flos Lonicerae Japonicae) and Lianqiao( Fructus Forsythiae) can be used to clear heat and resolve pathogens,Bohe( Herba Menthae) and Jiegeng( Radix Platycodonis) are adopted to disperse and facilitate lung qi,Zhizi( Fructus Gardeniae) and Dandouchi( Semen Sojae Praeparatum)are used to clear heat and relieve vexation. In cases complicated by lung qi deficiency,Jade Wind-Barrier Powder may be combined.When lung qi is clear and smooth,governance will be orderly,thereby assisting the smooth circulation of heart blood.

    2026 03 v.46;No.411 [Abstract][OnlineView][Download 150K]

  • Treatment of Knee Osteoarthritis Using Layered Penetrative Embedding Therapy Based on the Meridian-Sinew Theory

    WANG Xuexia;GUO Xiang;LIANG Shuang;GUO Xianhui;HE Zhenzi;The Third Affiliated Hospital of Henan University of Traditional Chinese Medicine;Henan University of Chinese Medicine;Management and Science University;

    Knee osteoarthritis( KOA) is characterized by the coexistence of sinew-bone disorders and flaccidity-bi syndrome,clinically presenting with knee pain,swelling,and functional impairment,etc. Layered penetrative thread-embedding therapy emphasizes precise placement according to the anatomical tissue layers beneath the acupoints,with particular attention to the depth of thread insertion.The embedding depth varies depending on the selected acupoints,therapeutic objectives,and individual patient characteristics. Based on the theory of layered penetrative thread-embedding therapy,and integrating the exterior-interior pattern differentiation,lesion depth,acupoint selection,and anatomical structure,appropriate thread lengths are selected for treatment. In KOA management,threads ranging from 1 to 3 cm in length are typically folded and embedded into both superficial layers( muscle fascia) and deep layers( tendons and ligaments). This technique represents an advancement beyond the conventional " Ashi-point-based" approach by integrating the TCM meridian-sinew theory with the modern kinetic chain concept. It proposes a stratified " muscle-sinew" treatment model. Commonly selected acupoints include Huantiao( GB30),Yanglingquan( GB34),Yinlingquan( SP9),Xuehai( SP10),Yingu( KI10),Zusanli( ST36),and Sanyinjiao( SP6). Currently,the application of layered penetrative thread-embedding therapy for KOA remains largely experience-based and lacks standardized quantitative protocols. Therefore,future research should focus on refining thread length selection and layer-specific precision according to anatomical structures,as well as conducting high-quality clinical trials and mechanistic studies to optimize the standardization and individualized application of this therapeutic approach.

    2026 03 v.46;No.411 [Abstract][OnlineView][Download 142K]

  • Research Progress of the Extraction and Purification and Antitumor Mechanisms of Polysaccharides from Chinese Medicinals

    WEN Xiyan;ZHOU Pengfa;YOU Jian;ZHANG Yan;LUO Yanyan;QIN Zhifu;Qingyang People's Hospital;Affiliated Hospital of Gansu University of Chinese Medicine;Gansu Provincial Hospital of Traditional Chinese Medicine;

    Polysaccharides are among the major active ingredients of Chinese medicinals,exhibiting a wide spectrum of pharmacological activities,including anti-aging,antitumor,antioxidant,antidepressant,and anti-osteoporotic effects. Various extraction techniques have been employed for the isolation of TCM polysaccharides,such as hot water extraction,ultrasonic-assisted extraction,enzymatic hydrolysis,acid/alkali extraction,and microwave-assisted extraction. Subsequent separation and purification are commonly achieved through column chromatography,microwave-assisted techniques,graded precipitation,ultrafiltration,ultrasonic methods,electrophoresis,and acid-base treatments,etc. The antitumor mechanisms of polysaccharides from Chinese medicinals primarily involve immune modulation,induction of tumor cell apoptosis,inhibition of tumor angiogenesis,and suppression of tumor cell proliferation. Although substantial progress has been made in elucidating their anti-tumor activities,several critical issues remain unresolved:( 1) Limited studies have focused on the regulation of tumor cell cycle progression by polysaccharides from Chinese medicinals.( 2) It remains unclear whether the pharmacological effects are attributable to intact polysaccharides or to their monosaccharide ingredients generated through in vivo hydrolysis.( 3) The relationship between antitumor efficacy and monosaccharide composition or ratio requires further clarification.( 4) The standardized production of polysaccharides lacks uniform standards. Therefore,future research should focus on key areas such as the precise structural analysis of polysaccharides from Chinese medicinals,in-depth investigation of their mechanisms of action,and evaluation of their clinical efficacy and safety. This will facilitate the clinical translation of polysaccharides from Chinese medicinals in oncology.

    2026 03 v.46;No.411 [Abstract][OnlineView][Download 155K]

  • A Meta Analysis of Genicular Nerve Radiofrequency Treatment for Knee Osteoarthritis

    ZHANG Yuhang;YANG Erkun;LU Rongfeng;XIE Bin;DU Dianhe;XU Yuankun;Guizhou University of Traditional Chinese Medicine;The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine;

    Objective: To systematically evaluate the efficacy of genicular nerve radiofrequency treatment for knee osteoarthritis( KOA).Methods: Randomized controlled trials( RCTs) on genicular nerve radiofrequency treatment for KOA were searched in CNKI,VIP,WanFang,Pub Med,Web of Science,and EMbase databases from inception to February 28,2025. A Meta-analysis was performed using RevMan 5. 3 software. Results: A total of 9 articles involving 855 patients and 9 studies were included. All studies had complete data and no selective reporting. Interventions in the control group included nerve block therapy,conventional analgesics,intra-articular steroid injections,sodium hyaluronate injections,sham operation,and joint lavage with sodium hyaluronate. Outcome measures covered Visual Analogue Scale( VAS) in 4 studies,Western Ontario and McMaster Universities Osteoarthritis Index( WOMAC) in 4 studies,Numerical Rating Scale( NRS) in 5 studies,Lysholm Knee Score in 2 studies,and Oxford Knee Score( OKS) in 2 studies. The Meta-analysis demonstrated statistically significant improvements in the radiofrequency group versus the control group for NRS,VAS,WOMAC,Oxford knee score( OKS),and Lysholm scores,and all the differences were statistically significant( P < 0. 05). The funnel plot was used to test for publication bias in the included studies,and the graph showed that the research points were symmetrically distributed within the inverted funnel,indicating that there was no significant publication bias in the included literature. Conclusion: Genicular nerve radiofrequency treatment shows favorable clinical efficacy for KOA. However,Currently,there is still a lack of multicenter,high-quality,large sample randomized controlled trials on the therapeutic effect of genicular nerve radiofrequency surgery on KOA patients,it is recommended for future studies to design more scientific and rigorous experimental plans,conduct long-term follow-up visits,and systematically summarize reports in future clinical trial observations to obtain more accurate clinical data on the efficacy of knee nerve radiofrequency surgery in treating KOA.

    2026 03 v.46;No.411 [Abstract][OnlineView][Download 445K]

  • Efficacy Observation of Decoction for Promoting Spleen Function and Resolving Phlegm and Lightening the Body Combined with Abdominal Vibration Cupping in Treating Metabolic Associated Steatotic Liver Disease

    ZHANG Hongyu;HOU Liufa;JIA Caixia;FENG Ya'nan;WANG Lei;LOU Jing;HAN Weifeng;Henan Integrative Medicine Hospital;

    Objective: To observe the clinical efficacy of Decoction for Promoting Spleen Function and Resolving Phlegm and Lightening the Body combined with abdominal vibration cupping on metabolic associated steatotic liver disease( MAFLD). Methods: A total of 108 patients with MAFLD were divided into the control group and the observation group according to the random number table method,with54 cases in each group. The control group received conventional Western medicine treatment,while the observation group received Decoction for Promoting Spleen Function and Resolving Phlegm and Lightening the Body combined with abdominal vibration cupping in addition to the treatment given to the control group. The clinical efficacy,incidence of adverse reactions,and changes in liver function[including alanine transaminase( ALT),aspartate aminotransferase( AST) ],blood lipids [triglyceride( TG),total cholesterol( TC),and high-density lipoprotein cholesterol( HDL-C) ],inflammatory factors [including tumor necrosis factor-α( TNF-α),interleukin-1β( IL-1β),and interleukin-8( IL-8) ],and serum liver fibrosis indicators [including procollagen type III( PC-Ⅲ),hyaluronic acid( HA),and laminin( LN) ]before and after treatment were compared between the two groups. Results: After treatment,ALT,AST,and TBIL levels in the two groups were all lower than those before treatment within the same group,and the observation group had lower levels than the control group,with statistically significant differences( P < 0. 05). TG and TC levels in the two groups were all lower than those before treatment within the same group,while HDL-C level was higher than that before treatment within the same group,with statistically significant differences( P < 0. 05). TNF-α,IL-1β,IL-8,PC-Ⅲ,HA,and LN levels in the two groups were lower than those before treatment within the same group,and the observation group had lower levels than the control group after treatment,with statistically significant differences( P < 0. 05). The effective rate in the observation group was 98. 15%,significantly higher than 77. 78% in the control group,with a statistically significant difference( P < 0. 05). The incidence of adverse reactions in the observation group was3. 70%,lower than 25. 93% in the control group,with a statistically significant difference( P < 0. 05). Conclusion: Decoction for Promoting Spleen Function and Resolving Phlegm and Lightening the Body combined with abdominal vibration cupping for MAFLD can significantly improve patients' liver function,blood lipid levels,inflammatory factors,and liver fibrosis indicators,enhance clinical efficacy,and has a lower incidence of adverse reactions.

    2026 03 v.46;No.411 [Abstract][OnlineView][Download 173K]

  • Historical Evolution and Textual Research on Formula Information of the Classical Famous Formula True Warrior Decoction

    WANG Lin;YANG Hongyu;LI Xueyan;YANG Rui;LI Yanying;WU Jiani;Tianjin University of Traditional Chinese Medicine;Beijing Increase Innovative Medicine Co.,Ltd.;

    Objective: To systematically review and analyze the historical origin,drug composition,formula analysis,original plant sources and processing,dosage and administration methods,pathogenesis,and main indications of True Warrior Decoction in order to conduct the textual research on its key information,and to analyze its status in modern clinical application. Methods:( 1) Ancient Literature Research: Full-text searches were conducted using " True Warrior Decoction" as the keyword in databases including the Knowledge Database of Ancient Chinese Medical Texts,the National Medical Canon Collection Database( V1. 0),the Chinese Medical Classics Database( V5. 0),and other online ancient book databases and specialized collections. Variant names,aliases,and abbreviations,etc. were also searched. When necessary,original ancient texts were consulted for data collection and content verification.( 2) Modern Literature Research: Computerized searches were performed in the China National Knowledge Infrastructure( CNKI),Wanfang Database,and VIP Database using subject headings or keywords such as " True Warrior Decoction" " clinical research" " clinical application" " treatment" " clinical report" " clinical case" " efficacy observation" and " clinical observation". The search covered literature related to True Warrior Decoction published from the inception of each database until February 2025. Results:( 1) Textual Research on Ancient Literature:A total of 131 valid data entries were included,involving 120 ancient books. The research indicated that True Warrior Decoction originated from Zhang Zhongjing's Treatise on Cold Damage Diseases in the Eastern Han Dynasty. It is composed of Fuling( Poria),Baishao( Radix Paeoniae Alba),Shengjiang( Rhizoma Zingiveris Recens),Baizhu( Rhizoma Atractylodis Macrocephalae),and Fuzi( Radix Aconiti Lateralis Preparata). It is a representative formula for warming yang and inducing diuresis,commonly used for treating greater yang disease and lesser yin disease syndromes. It can also treat conditions such as deficiency in both the exterior and interior,phlegm and wheezing,yang deficiency of the bladder,spleen-kidney deficiency,and external cold coupled with water retention.( 2) Modern Clinical Application: A total of 51 valid articles were included. The related analysis showed that True Warrior Decoction is primarily used to treat chronic heart failure,nephrotic syndrome,benign prostatic hyperplasia,hypertension,and other diseases with significant therapeutic effects. Conclusion: Through systematic review and textual research on ancient and modern literature on True Warrior Decoction,its historical evolution and core application patterns have been clarified,which provides a more substantial basis for the rational clinical application and development of True Warrior Decoction.

    2026 03 v.46;No.411 [Abstract][OnlineView][Download 193K]

  • Optimization of Blood Deficiency Models Based on the Blood-Nourishing Validation of Intestine-Moistening Pills

    LONG Qian;QIAO Nan;CHENG Shuqi;NIE Min;LI Qi;HU Jia;JIANG Yiping;XU Song;ZHENG Qiongna;Graduate School,Jiangxi University of Chinese Medicine;School of Clinical Medicine,Jiangxi University of Chinese Medicine;Jiangxi Flight University;National Inheritance Studio of Renowned Veteran TCM Expert Jiang Yiping;Yueqing Hospital Affiliated to Wenzhou Medical University;

    Objective: To optimize animal models that align with the characteristics of blood deficiency and whose application performances are validated by blood-nourishing verification in TCM. Methods: A total of 96 male SD rats were randomly divided into three stages: cyclophosphamide( CTX) modeling,acetylphenylhydrazine( APH) modeling,and Intestine-Moistening Pills gradient validation.The first two stages were used to select the optimal method for inducing blood deficiency,and the third stage involved administering Intestine-Moistening Pills to validate the application performance of the optimized model. The general condition,blood routine parameters,fecal water content,and colonic transit time of the rats were compared and analyzed. Results: Low-dose CTX failed to induce a blood deficiency state,as indicated by no significant decrease in red blood cell( RBC) count,hemoglobin( HGB),or hematocrit( HCT) in blood routine tests( P > 0. 05). Medium and high doses of CTX tended to cause high mortality in the test animals. APH exhibited a low mortality rate and successfully induced a blood deficiency state,characterized by significant decreases in RBC,HGB,and HCT( P <0. 05). Notably,a low dose of APH( 20 mg·kg~(-1),administered for 3 days) alone was sufficient to facilitate the blood-nourishing validation of different doses of Intestine-Moistening Pills,as evidenced by the recovery of RBC,HGB,and HCT. In the blood deficiency state,model animals showed defecation disorders such as decreased fecal water content and prolonged colonic transit time( P < 0. 05).Conclusion: A low dose of APH can successfully establish an animal model conforming to the characteristics of blood deficiency,whose application performance is verified through the blood-nourishing efficacy of Intestine-Moistening Pills.

    2026 03 v.46;No.411 [Abstract][OnlineView][Download 341K]

  • Exploring the Mechanism of Huangqi in Treating Coronary Heart Disease Through Network Pharmacology and Mendelian Randomization

    ZHANG Jing;WANG Qingyan;SUN Fengxiao;DONG Bo;Shandong University of Traditional Chinese Medicine;Provincial Hospital Affiliated to Shandong First Medical University;

    Objective: To investigate the mechanism of Huangqi( Radix Scutellariae) in treating coronary heart disease( CHD) by integrating network pharmacology and Mendelian randomization analysis. Methods: Active components and targets of Huangqi were retrieved from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform( TCMSP). CHD-related targets were obtained from the Gene Cards database. Intersection targets were identified using a Venn online tool and visualized in a Venn diagram. The STRING database was used to analyze the intersection targets,and the Cytoscape 3. 10. 2 software was imported to construct the PPI network. Topological analysis was conducted to identify the core targets of Huangqi in the treatment of CHD. Gene Ontology( GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes( KEGG) pathway analysis were performed using the Microbioinformatics platform. GO analysis included three modules: molecular function( MF),cellular component( CC),and biological process( BP). Molecular docking was performed and binding energy was calculated using Autodock Tools 1. 5. 6 software. Mendelian randomization was used to eliminate confounding factors and verify at the gene level. Results: TCMSP screening identified 17 active components of Astragalus and 195 associated targets,while Gene Cards provided 1,466 CHD-related targets. The intersection of the target points related to the active components of Huangqi and the target points of CHD was taken and a Venn diagram was drawn,resulting in108 intersection target points. The intersection target points were imported into the STRING database to construct a PPI network,and a topological analysis was used to screen out 14 core target points. GO analysis generated 1,895 BPs,51 CCs,and 135 MFs. KEGG pathway analysis identified 146 signaling pathways. Molecular docking demonstrated binding energies <-5 kcal·mol~(-1)for 7 active components,with particularly high binding affinity for JUN and MAPK157. Mendelian randomization confirmed a causal relationship between IL-1β and CHD5. Molecular docking showed that the binding energies of 7 active components of Huangqi to the core targets were all less than-5 kcal·mol~(-1),and the binding energies to the JUN and MAPK1 targets were relatively high. After excluding the influence of confounding factors through Mendelian randomization studies,it was confirmed that there was a causal relationship between IL-1β and CHD. Conclusion: This study has confirmed from multiple perspectives that Huangqi can play a therapeutic role in CHD by regulating multiple targets and multiple pathways.

    2026 03 v.46;No.411 [Abstract][OnlineView][Download 330K]

  • Liu Xin's Experience in Treating Acute-Stage Henoch-Sch??nlein Purpura with Wind-Dispelling and Spot-Removing Decoction

    YUAN Lingyun;LIU Xin;ZHANG Xiaoliang;SUN Minghe;ZHANG Jun;Liaoning University of Traditional Chinese Medicine;The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine;

    Professor Liu Xin holds that wind-heat toxin is the primary etiological factor for acute-stage henoch-sch??nlein purpura( HSP),and blood stasis serves as an extremely important pathogenic factor and pathological product throughout the entire course of the disease. The main pathogenesis involves excessive heat-toxin forcing the blood to move recklessly,obstruction by blood stasis leading to extravasation of blood from the vessels,and deficiency of both qi and yin allowing pathogenic factors to linger. The treatment of HSP during the acute stage is crucial for the disease progression and prognosis,therefore,emphasis should be placed on early intervention during acute stage,addressing both the root cause and the symptoms concurrently. The acute stage is characterized by excessive pathogenic factors,commonly presenting as wind-heat damaging the collaterals syndrome or heat enabling frenetic movement of blood syndrome,and may also be accompanied by dampness-heat accumulating internally syndrome. Professor Liu adopts the therapeutic principle of clearing heat,detoxifying,cooling the blood,and stopping bleeding. She has formulated Wind-Dispelling and Spot-Removing Decoction for treating acute-stage HSP,which achieves multi-target intervention to suppress vascular inflammatory response. The formula is meticulously composed to treat both the root and the branch causes,aligning with the treatment principles for the acute stage. For abdominal pain,Baishao( Radix Paeoniae Alba) 20 g and Yanhusuo( Rhizoma Corydalis) 20 g are added. For diarrhea,Shanyao( Rhizoma Dioscoreae)20 g and stir-fried Lianzi( Semen Nelumbinis) 15 g are added. For joint distension and pain,Yanhusuo( Rhizoma Corydalis) 15 g and Qinjiao( Radix Gentianae Macrophyllae) 15 g are added. For dry mouth,Tianhuafen( Radix Trichosanthis) 15 g and Maidong( Radix Ophiopogonis) 15 g are added. For sore throat,Niubangzi( Fructus Arctii) 10 g is added. Furthermore,Professor Liu emphasizes that the treatment of acute-stage HSP requires precise syndrome differentiation,accurately targeting the pathogenesis. In clinical practice,she prioritizes modifying formulas based on syndrome presentation,applying them flexibly,and also focuses on regulation and care to prevent recurrence.

    2026 03 v.46;No.411 [Abstract][OnlineView][Download 144K]

  • An Analysis of Feng Zhihai's Academic Thought of the "Disease-Syndrome-Symptom" Trinity in the Diagnosis and Treatment of Goiter

    SHAN Liufeng;FENG Zhihai;Zhengzhou Traditional Chinese Medicine Hospital;The First Affiliated Hospital of Henan University of Chinese Medicine;

    Professor Feng Zhihai has proposed the academic thought of the " disease-syndrome-symptom" trinity in the diagnosis and treatment of goiter. The core lies in the precise grasp of the pathogenesis of " disease," dynamic syndrome differentiation of " syndrome," and the organic integration of targeted improvement of " symptoms" and " indicators," thus forming a three-dimensional diagnostic and therapeutic system characterized by " differentiation of disease as the foundation,differentiation of syndrome as the guideline,and treatment of symptoms as the manifestation. " Professor Feng holds that the basic pathogenesis of goiter is qi stagnation,phlegm coagulation,and blood stasis obstructing the anterior neck. The main sites of disease are the liver and spleen,and emotional factors are the principal etiological factors,therefore,regulating the liver is primary in diagnosis and treatment. Formulas such as Free Wanderer Powder,Bupleurum Liver-Soothing Powder,Gardenia Liver-Clearing Decoction,Effective Integration Decoction,etc. are frequently modified and prescribed to clear,soothe,pacify,and nourish the liver. With regard to " syndrome," Professor Feng emphasizes syndrome differentiation according to different types of goiter and different stages. Hyperthyroidism in the early stage is mostly differentiated as liver depression with exuberant fire; subacute thyroiditis in the early stage is mostly differentiated as exuberant heat-toxin; hypothyroidism is mostly differentiated as spleen-kidney yang deficiency; and thyroid nodules are mostly differentiated as phlegm coagulation with blood stasis. Professor Feng also stresses the treatment of " symptoms" and " indicators. " According to different clinical manifestations,different " symptom-targeted" and " indicator-targeted" medicinals are administered: For hyperhidrosis,calcined Longgu( Os Draconis),calcined Muli( Concha Ostreae),and Wuweizi( Fructus Schisandrae),etc. are added to astringe sweating. For anxiety and insomnia,Ciwujia Pi( Cortex Acanthopanacis),Guanyejinsitao( Herba Hyperici),and Yuanzhi( Radix Polygalae),etc. are added. For frequent stools,Chishizhi( Halloysitum Rubrum),Yuyuliang( Limonitum),and Shiliupi( Pericarpium Granati),etc. are added. For patients with Hashimoto's thyroiditis with high antibody levels,Chuanshanlong( Dioscorea nipponica),Xiakucao( Spica Prunellae),and Leigongteng( Tripterygium wilfordii),etc. are added on the basis of disease and syndrome differentiation. For thyroid nodules,Xiakucao( Spica Prunellae),Maozhuacao( Radix Ranunculi ternati),Zhebeimu( Bulbus Fritillariae Thunbergii),Ezhu( Rhizoma Curcumae),and Lianqiao( Fructus Forsythiae),etc. are frequently added. In clinical practice,Professor Feng follows the theory of " concurrent treatment of interrelated conditions. " In the treatment of hyperthyroidism in goiter,Free Wanderer Powder and Celestial Emperor Heart-Supplementing Elixir are often modified and used to regulate the liver and spleen,and to treat the heart and liver together. Professor Feng also attaches importance to local external application therapy in treating goiter,formulating Goiter-Resolving and Pain-Alleviating Powder for external application to the thyroid region for subacute thyroiditis with exuberant heat-toxin. He also emphasizes comprehensive traditional Chinese medicine therapy,adopting emotional counseling,dietary adjustment,music therapy,and other approaches for overall regulation.

    2026 03 v.46;No.411 [Abstract][OnlineView][Download 141K]

  • Clinical Study on Stasis-Removing and Collateral-Dredging Method Combined with Minimally Invasive Plate Osteosynthesis in the Treatment of Humeral Shaft Fractures

    LI Haoliang;LI Dongfang;The Second Affiliated Hospital of Henan University of Chinese Medicine,Henan Province Hospital of Traditional Chinese Medicine;

    Objective: To observe the clinical efficacy of stasis-removing and collateral-dredging method combined with minimally invasive plate osteosynthesis( MIPO) on humeral shaft fractures. Methods: A total of 92 patients with humeral shaft fractures treated with MIPO were divided into the routine group and the experimental group using the random number table method,with 46 cases in each group. The routine group received conventional postoperative treatment,while the experimental group was treated with stasis-removing and collateral-dredging method in addition to the conventional treatment received by the routine group. Then operation time,fracture healing time,swelling resolution time,hospital stay,pain resolution time,inflammatory factors [including C-reactive protein( CRP),interleukin( IL)-1β,IL-6,and tumor necrosis factor( TNF)-α],visual analogue scale( VAS) score for pain,Neer score for shoulder joint function,Mayo score for elbow joint function,and the occurrence of complications were observed and compared between the two groups. Results: The fracture healing time,swelling resolution time,hospital stay,and pain resolution time in the experimental group were shorter than those in the routine group,with statistically significant differences between the two groups( P < 0. 05). However,there was no statistically significant difference in operation time between the experimental group and the routine group( P > 0. 05). The levels of CRP,IL-1β,IL-6,and TNF-α in the experimental group at the 2 nd week after operation were lower than those in the routine group,with statistically significant differences( P < 0. 05). The VAS scores in the experimental group at the 2 nd and 4 th week after operation were lower than those in the routine group,with statistically significant differences( P < 0. 05). The Mayo elbow function scores and Neer shoulder function scores in the experimental group at the 4 th and 12 th week after operation were higher than those in the routine group,with statistically significant differences( P < 0. 05). The complication rate was 6. 51% in the experimental group and 10. 86% in the routine group,with no statistically significant difference between the two groups( P > 0. 05). The difference in the incidence of adverse reactions between the two groups was not statistically significant( P > 0. 05). Conclusion: The stasis-removing and collateral-dredging method combined with MIPO can reduce the levels of inflammatory factors,promote the resolution of pain and swelling,and improve elbow and shoulder joint function in patients with humeral shaft fractures.

    2026 03 v.46;No.411 [Abstract][OnlineView][Download 161K]

  • Clinical Study on Liver-Soothing and Gallbladder-Warming Decoction Combined with Auricular Point Seed-Embedding in the Treatment of Unstable Angina

    FENG Weijie;Luoning County Hospital of Traditional Chinese Medicine;

    Objective: To observe the clinical efficacy of Liver-Soothing and Gallbladder-Warming Decoction combined with auricular point seed-embedding therapy on unstable angina( UA). Methods: A total of 78 UA patients diagnosed and treated at Luoning County Hospital of Traditional Chinese Medicine between March 2022 and December 2024 were selected and randomly divided into the observation group and the control group,with 39 cases in each group. The control group received conventional Western medicine treatment,while the observation group received Liver-Soothing and Gallbladder-Warming Decoction combined with auricular point seed-embedding therapy in addition to the conventional treatment. Changes in TCM syndrome scores,cardiac function [including cardiac output( CO),cardiac index( CI),Seattle Angina Questionnaire( SAQ) score] before and after treatment,as well as clinical efficacy and the incidence of adverse reactions,were observed between the two groups. Results: The effective rate was 74. 36% in the control group and92. 31% in the observation group. The effective rate in the observation group was higher than that in the control group,with a statistically significant difference( P < 0. 05). After treatment,TCM syndrome scores decreased in both groups compared to before treatment,and the scores in the observation group were significantly lower than those in the control group,with statistically significant differences( P <0. 05). The levels of CO,CI,and SAQ scores increased in both groups compared to before treatment,and the above levels in the observation group were significantly higher than those in the control group,with statistically significant differences( P < 0. 05). The incidence of adverse reactions was 5. 13% in the control group and 12. 82% in the observation group,but there was no statistically significant difference between the two groups( P > 0. 05). Conclusion: Liver-Soothing and Gallbladder-Warming Decoction combined with auricular point seed-embedding therapy for UA can improve clinical efficacy,alleviate symptoms and signs,and effectively protect patients' cardiac function.

    2026 03 v.46;No.411 [Abstract][OnlineView][Download 157K]

  • Clinical Study on the Combination of Liver-Clearing Anticancer Formula and Lenvatinib Mesylate in the Treatment of Primary Liver Cancer

    WEI Gaopeng;Henan Provincial Infectious Disease Hospital;

    Objective: To observe the clinical efficacy of Liver-Clearing Anticancer Formula combined with Lenvatinib Mesylate on primary liver cancer. Methods: A total of 83 patients with primary liver cancer treated at Henan Provincial Infectious Disease Hospital from August 2022 to August 2023 were selected and randomly divided into the control group with 40 cases and the observation group with 43 cases using the random number table method. The control group received Lenvatinib Mesylate,while the observation group additionally received Liver-Clearing Anticancer Formula. The clinical efficacy,changes in immune function,liver function,and tumor diameter before and after treatment were compared between the two groups. Results: The effective rate in the observation group was 88. 37%,significantly higher than that in the control group: 67. 50%,with a statistically significant difference( P < 0. 05). After treatment,the levels of serum NK cells and immunoglobulin G in the observation group were higher than those in the control group,with a statistically significant difference( P < 0. 05); serum γ-glutamyl transpeptidase,alanine aminotransferase,and aspartate aminotransferase levels in the observation group were lower than those in the control group,with statistically significant differences( P < 0. 05); the tumor diameter in the observation group was smaller than that in the control group,with a statistically significant difference( P < 0. 05). Conclusion: The combination of Liver-Clearing Anticancer Formula and Lenvatinib Mesylate can improve clinical efficacy in treating primary liver cancer,which may be related to enhancing immune function,ameliorating liver function abnormalities,and reducing tumor diameter,etc.

    2026 03 v.46;No.411 [Abstract][OnlineView][Download 147K]

  • Efficacy Observation of Lung-Supplementing and Exterior-Securing and Cold-Dispersing Decoction in Treating Allergic Rhinitis

    LI Caihong;TONG Zhenjiang;WANG Hongguang;The Third Affiliated Hospital of Henan University of Traditional Chinese Medicine;

    Objective: To observe the clinical efficacy of Lung-Supplementing and Exterior-Securing and Cold-Dispersing Decoction on allergic rhinitis( AR) and its effect on patients' immune function,and peripheral blood regulatory T cells( Treg)/T helper 17 cells( Th17). Methods: A total of 178 patients with AR treated at The Third Affiliated Hospital of Henan University of Traditional Chinese Medicine from January 2022 to December 2024 were selected and randomly divided into the control group and the observation group according to the random number table method,with 89 cases in each group. During the treatment process,4 cases dropped out in the observation group and 2 in the control group,resulting in a final count of 85 cases in the observation group and 87 in the control group.The control group received conventional Western medical treatment,while the observation group was additionally treated with Lung-Supplementing and Exterior-Securing and Cold-Dispersing Decoction on the basis of the control group' s treatment. The clinical efficacy,changes in TCM syndrome scores,peripheral blood Treg/Th17 cell levels,transforming growth factor( TGF)-β1 and interleukin( IL)-17 levels,serum inflammatory factor levels [immunoglobulin E( Ig E),IL-10,and interferon-γ( IFN-γ) ]before and after treatment were compared between the two groups. Results: After treatment,the TCM syndrome scores in the two groups were lower than those before treatment within their respective groups,and the observation group's score was lower than that of the control group( P < 0. 05). The effective rate was 80. 46% in the control group and 92. 94% in the observation group,with a statistically significant difference between the two groups( P < 0. 05). After treatment,Treg and TGF-β1 levels in the two groups were higher than those before treatment within their respective groups,while Th17 and IL-17 levels were lower than those before treatment within their respective groups,and the differences were statistically significant between the two groups( P < 0. 05). Serum Ig E level in the two groups was lower than that before treatment within their respective groups,while IL-10 and IFN-γ levels were higher than those before treatment within their respective groups,and all the differences between the two groups were statistically significant( P < 0. 05). Conclusion: Lung-Supplementing and Exterior-Securing and Cold-Dispersing Decoction is effective in improving symptoms,regulating the imbalance of Treg/Th17 cells,and significantly alleviating inflammatory reactions in patients with AR.

    2026 03 v.46;No.411 [Abstract][OnlineView][Download 155K]

  • An Analysis of Traditional Chinese Medicine Syndrome Type Distribution and Related Risk Factors in Children with Pneumonia

    XU Ping;ZHOU Taocheng;Anhui Provincial Children's Hospital;

    Objective: To analyze the distribution of TCM syndrome types and disease severity in children with pneumonia,and to explore their correlations with related risk factors such as clinical data,etc.,in order to provide references for clinical syndrome differentiation and treatment. Methods: Clinical data from 430 children with pneumonia admitted to Anhui Provincial Children's Hospital were collected,including gender,age,history of previous respiratory diseases,TCM syndrome type,pneumonia severity classification,duration of cough,duration of fever,peak fever temperature,pathogen infection status,respiratory symptom score,gastrointestinal symptom score,and laboratory indicators [including white blood cell count( WBC),neutrophil count,platelet count( PLT),C-reactive protein( CRP),and procalcitonin( PCT) ]. The distribution of TCM syndrome types and disease severity among the children with pneumonia was counted,the correlations with clinical data were statistically analyzed,and risk factors related to the classification of pneumonia severity were also investigated. Results: Among 430 children with pneumonia,the TCM syndrome type distribution was as follows: 192 cases of windheat obstructing the lung syndrome,170 cases of phlegm-heat obstructing the lung syndrome,33 cases of toxic-heat obstructing the lung syndrome,13 cases of dampness-heat obstructing the lung syndrome,and 12 cases of lung-spleen qi deficiency syndrome. Regarding disease severity,361 cases were mild and 69 were severe. In terms of infection,335 cases had single infections and 95 had mixed infections. The rate of single infection was higher than that of mixed infection across all TCM syndrome types,and the differences were statistically significant between wind-heat obstructing the lung syndrome,phlegm-heat obstructing the lung syndrome,and lung-spleen qi deficiency syndrome( P < 0. 05). The proportion of mild cases was higher than severe cases among children with wind-heat obstructing the lung syndrome and phlegm-heat obstructing the lung syndrome,whereas the proportion of severe cases was higher than mild cases among those with toxic-heat obstructing the lung syndrome and dampness-heat obstructing the lung syndrome,with statistically significant differences( P < 0. 05). No statistically significant difference was found in pneumonia severity classification for children with lungspleen qi deficiency syndrome( P > 0. 05). There were no statistically significant differences in gender,age group,or history of previous respiratory diseases among children with different pneumonia severity classifications( P > 0. 05). However,a statistically significant difference was observed in pathogen infection among children with different pneumonia severity classifications( P < 0. 05). Statistically significant differences were found among children with different TCM syndrome types in terms of WBC,SII,CRP,PCT,respiratory symptom scores,gastrointestinal symptom scores,peak fever temperature,and durations of fever and cough( P < 0. 05). No statistically significant differences were observed in WBC,CRP,or LDH among children with different pneumonia severity classifications( P > 0. 05).However,statistically significant differences were found for SII,PCT,respiratory symptom scores ≥ 34,gastrointestinal symptom scores ≥8,cough duration ≥11 days,fever duration ≥7 days,and peak fever temperature ≥39. 1 ℃( P < 0. 05). Logistic regression analysis revealed that fever duration ≥7 days,SII > 1,000 × 10~9·L~(-1),gastrointestinal symptom scores ≥8,mixed infections,dampness-heat obstructing the lung syndrome,and toxic-heat obstructing the lung syndrome were independent risk factors for severe pneumonia( P < 0. 05). Conclusion: Among 430 children with pneumonia,mild cases and wind-heat obstructing the lung syndrome were the most common types. Toxic-heat obstructing the lung syndrome and dampness-heat obstructing the lung syndrome were closely associated with severe pneumonia. Mixed infections,prolonged fever duration,elevated SII,and gastrointestinal symptoms were major risk factors for severe pneumonia.

    2026 03 v.46;No.411 [Abstract][OnlineView][Download 183K]

  • Exploring the Clinical Efficacy of Fluid-Increasing and Defecation-Promoting Decoction in Treating Slow Transit Constipation Based on the Theory of "Large Intestine Governing Body Fluids" and the Mechanism of Action of "Adding Water to Float a Boat"

    ZHOU Fengrui;YANG Huiju;ZHANG Miao;JIA Feiliang;The Third Affiliated Hospital of Henan University of Chinese Medicine;Henan University of Chinese Medicine;

    Objective: To explore the clinical efficacy of Fluid-Increasing and Defecation-Promotin on slow transit constipation( STC)and the mechanism of action of its " adding water to float a boat",based on the theory of " large intestine governing body fluids. " Methods: A total of 67 hospitalized patients with STC( with syndrome of intestinal dryness due to yin deficiency) at The Third Affiliated Hospital of Henan University of Traditional Chinese Medicine from January 2024 to January 2025 were selected as subjects and randomly divided into the control group with 33 cases and the observation group with 34 cases using the random number table method. The control group received lactulose syrup for oral administration,while the observation group received oral Fluid-Increasing and DefecationPromoting Decoction. The changes in constipation symptom scores,TCM syndrome scores,gastrointestinal function levels [including serum motilin( MTL),substance P( SP),and vasoactive intestinal peptide( VIP) ],intestinal microbiota content,aquaporin( AQP) expression,colon transit test results before and after treatment,and clinical efficacy were observed in the two groups. Results: The effective rate was 91. 18% in the observation group,which was higher than 84. 85% in the control group,with a statistically significant difference( P < 0. 05). After treatment,TCM syndrome scores were lower than those before treatment in the two groups,with statistically significant differences( P < 0. 05). Constipation symptom scores were lower than those before treatment in the two groups,with statistically significant differences( P < 0. 05). The levels of MTL and SP were significantly higher,while VIP levels were significantly lower in the observation group compared with the control group,with statistically significant differences( P < 0. 05). The levels of enterobacteria were significantly lower,while levels of bifidobacterium,lactobacillus,and butyric acid were significantly higher in the observation group compared with the control group,with statistically significant differences( P < 0. 05). The levels of AQP3 and AQP9 were lower than those before treatment in the two groups,and the above levels were significantly lower in the observation group compared with the control group,with statistically significant differences( P < 0. 05). The observation group had a significantly higher amount of stool excretion at24 h,48 h,and 72 h compared with the control group,and the difference was statistically significant( P < 0. 05). Conclusion: Fluid-Increasing and Defecation-Promoting Decoction can significantly improve constipation symptoms and TCM syndromes in STC patients with syndrome of intestinal dryness due to yin deficiency,and promote colonic transit motility. The mechanism by which it exerts its " adding water to float a boat" effect may be related to regulating gastrointestinal hormones,modulating aquaporin expression,and maintaining intestinal microbiota balance.

    2026 03 v.46;No.411 [Abstract][OnlineView][Download 194K]

  • Clinical Study on Modified Yinqiao Powder Combined with Wind-Dispersing and Exterior-Releasing Acupuncture for Treating of Pityriasis Rosea

    ZHU Xiaohui;LU Haisong;The Third Affiliated Hospital of Henan University of Traditional Chinese Medicine;

    Objective: To observe the clinical efficacy of Modified Lonicera and Forsythia Powder combined with wind-dispersing and exterior-releasing acupuncture on pityriasis rosea. Methods: A total of 86 patients with pityriasis rosea were divided into the control group and the combined group according to the random number table method,with 43 cases in each group. The control group received conventional treatment combined with wind-dispersing and exterior-releasing acupuncture,while the combined group received additional Modified Lonicera and Forsythia Powder on the basis of the control group's treatment. The clinical efficacy,symptom improvement,changes in disease severity scores,levels of laboratory indicators [including vascular cell adhesion molecule-1( VCAM-1),interleukin-17( IL-17),and malondialdehyde( MDA) ],and quality of life scores before and after treatment were compared between the two groups. Results: The effective rate in the combined group was 86. 05%,which was higher than 62. 79% in the control group,and the difference was statistically significant( P < 0. 05). After treatment,the time to itch relief,cessation of new rash eruption,and complete healing of skin lesions in the combination group were shorter than those in the control group,with statistically significant differences( P < 0. 05).The severity scores for the number of lesions,erythema,infiltration,scaling,and the quality of life scores in the two groups were lower than those before treatment within the same group. Furthermore,the above scores in the combined group were lower than those in the control group,with statistically significant differences( P < 0. 05). The levels of VCAM-1,MDA,and IL-17 in the two groups were lower than those before treatment within the same group. Additionally,the levels in the combined group were lower than those in the control group,with statistically significant differences( P < 0. 05). Conclusion: Modified Lonicera and Forsythia Powder combined with winddispersing and exterior-releasing acupuncture shows significant efficacy in treating pityriasis rosea. It can effectively shorten the disease course and improve clinical symptoms. Its mechanism of action may be related to regulating inflammatory responses and oxidative stress levels.

    2026 03 v.46;No.411 [Abstract][OnlineView][Download 167K]

  • Efficacy Observation of Wind-Dispersing Powder Combined with Ductoscopic Perfusion in the Treatment of Plasma Cell Mastitis

    ZHAO Suzhen;LI Su;ZHANG Lulu;YANG Mengmeng;FAN Yan;The Second Affiliated Hospital of Henan University of Chinese Medicine,Henan Province Hospital of Traditional Chinese Medicine;

    Objective: To observe the clinical efficacy of Wind-Dispersing combined with ductoscopic perfusion on plasma cell mastitis( PCM) and its effect on the Janus kinase 2( JAK2)/signal transducer and activator of transcription 3( STAT3) signaling pathway in patients. Methods: A total of 84 PCM patients were randomly divided into the control group and the treatment group using the random number table method,with 42 cases in each group. The control group received ductoscopic perfusion treatment,while the treatment group received Wind-Dispersing Powder in addition to the treatment administered to the control group. The clinical efficacy,recurrence rate,and changes in breast symptom scores,levels of inflammatory factors [including interleukin( IL)-1β,IL-6,tumor necrosis factor-α( TNF-α) ],and levels of JAK2/STAT3 pathway-related proteins before and after treatment were compared between the two groups. Results: The effective rate in the treatment group was 95. 24%,which was higher than 80. 95% in the control group,and the difference was statistically significant( P < 0. 05). After treatment,the scores for mass diameter,mass range,pain degree,and skin condition in the two groups were all lower than those before treatment within each group. Furthermore,after treatment,these scores in the treatment group were lower than those in the control group,with statistically significant differences( P < 0. 05). The levels of IL-1β,IL-6,and TNF-α in the two groups were all lower than those before treatment within each group,and these levels in the treatment group were lower than those in the control group,with statistically significant differences( P < 0. 05). The ratios of p-JAK2/JAK2 and p-STAT3/STAT3 in the two groups were all lower than those before treatment within each group. Additionally,these ratios in the treatment group were lower than those in the control group,with statistically significant differences( P < 0. 05). The recurrence rate was 5% in the treatment group,which was lower than 20. 59% in the control group,and the difference was statistically significant( P < 0. 05). Conclusion: Wind-Dispersing combined with ductoscopic perfusion in treating PCM can enhance clinical efficacy,improve clinical symptoms,reduce the levels of inflammatory factors and the recurrence rate,and inhibit the phosphorylation of JAK2/STAT3 pathway-related proteins. The mechanism of action may be related to the multi-target regulation of the JAK2/STAT3 signaling pathway by Wind-Dispersing Powder,thereby inhibiting the expression of downstream inflammatory factors.

    2026 03 v.46;No.411 [Abstract][OnlineView][Download 171K]

  • Evidence Mapping of Clinical Study on Scraping Intervention for Patients with Neck-Shoulder-Low Back-Leg Pain

    LI Mengyuan;SHI Hui;XU Haixia;MA Wenjing;LI Chaojun;Anhui University of Chinese Medicine;The First Affiliated Hospital of Anhui University of Chinese Medicine;

    Objective: To systematically review and present the overall evidence landscape of existing clinical study on scraping intervention for patients with neck,shoulder,low back,and leg pain using evidence mapping,thereby providing a reference for clinical practice and subsequent research. Methods: A systematic search was conducted for randomized controlled trials( RCTs) related to scraping intervention for neck,shoulder,low back,and leg pain in the following databases: CNKI,Wanfang,VIP,Sino Med,Pub Med,Web of Science,Cochrane Library,and Embase,from their inception to November 10,2024. The methodological quality of the included literature was assessed according to the Cochrane Handbook for Systematic Reviews of Interventions. The characteristics of evidence distribution were presented using a combination of charts and graphs. Results: The initial search yielded 5,093 articles. After removing 3,580 duplicates using Note Express software,and excluding 1,032 articles based on title/abstract screening and 251 articles based on full-text review,230 articles were finally included. These comprised 228 Chinese and 2 English publications,with the overall publication volume showing a fluctuating upward trend. Clusters #0 cervical spondylosis,#1 pain,#2 moxibustion,and #3 nursing have persisted from their initial years of appearance to the present. Among them,cluster #0 cervical spondylosis spanned the longest period,from 2003 to 2024. " Copper scraping scraping," " pain," " warming-dredging scraping," and " dysfunction" were the prominent keywords in 2021 and 2022,with research interest continuing to the present,and " pain" having the strongest burst intensity. The included studies involved 17 different syndromes,with the top three being cervical spondylosis,lumbar disc herniation,and periarthritis of the shoulder. Among the included RCTs,few studies incorporated syndrome differentiation according to TCM,with only 36 articles( 15. 65%) doing so. These covered 12 TCM syndrome types,primarily qi stagnation and blood stasis,cold-dampness obstruction,and liver-kidney deficiency. Regarding scraping tools,buffalo horn scraping boards were the most common( 18. 70%),followed by innovative tools like copper scraping boards( 15. 65%) and warming-dredging scrappingcups( 13. 04%). In terms of application methodology,meridian-based scraping therapy was the most frequent( 58. 26%),followed by acupoint-based scrapping( 22. 61%) and holographic theory-based scraping( 2. 61%). Regarding intervention frequency,1-2 times per week was most common( 124 articles,53. 91%),while 5-7 times per week was least common( 17 articles,7. 39%). A total of 20 articles did not specify the scraping intervention frequency. Conclusion: Scraping therapy is widely used and shows certain efficacy in clinical research for intervening in neck,shoulder,low back,and leg pain,with ongoing innovation in tools and application theories. However,the quality of the literature is generally poor,characterized by shortcomings such as small sample sizes,inconsistent intervention frequencies and periods,neglect of TCM syndrome differentiation,and a lack of objective outcome measures,etc. Therefore,future efforts should focus on conducting more high-quality,large-sample,standardized clinical study to provide stronger evidence-based medical and clinical intervention references.

    2026 03 v.46;No.411 [Abstract][OnlineView][Download 464K]

  • The Effect of Time-selective Balanced Acupuncture Combined with Acupoint Acupressure Massage Based on the Meridian-Sinew Theory on Patients with Neck-Shoulder-Low Back-Leg Pain

    ZHAI Pei;SUN Yongqiang;LIU Guojie;LU Shaofang;Luoyang Orthopedic-Traumatological Hospital of Henan Province,Henan Provincial Orthopedic Hospital;

    Objective: To observe the effect of time-selective balanced acupuncture combined with acupoint acupressure massage based on the meridian-sinew theory on patients with neck,shoulder,low back,and leg pain. Methods: A total of 96 patients with neck,shoulder,low back,and leg pain admitted to Luoyang Orthopedic-Traumatological Hospital of Henan Province,and Henan Provincial Orthopedic Hospital from June 2022 to June 2024 were selected and randomly divided into the control group and the combined group using the random number table method,with 48 cases in each group. The control group received acupoint acupressure massage treatment,while the combined group received time-selective balanced acupuncture based on the meridian-sinew theory combined with acupoint acupressure massage. Then the changes in hemodynamic indicators [including hematocrit( HCT),plasma viscosity( PV),and erythrocyte sedimentation rate( ESR) ],prostaglandin E2( PGE2),nerve growth factor( NGF),5-hydroxytryptamine( 5-HT),visual analogue scale( VAS) scores,motor ability [including Fugl-Meyer assessment of motor recovery after stroke( FMA),and modified Barthel index( MBI) ],TCM syndrome scores before and after treatment,and the clinical efficacy were observed in the two groups. Results: After treatment,the levels of hemodynamic indicators such as HCT,PV,and ESR in the combined group were lower than those in the control group,with statistically significant differences( P < 0. 05). The PGE2,NGF,5-HT levels,and VAS scores in the combined group were lower than those in the control group,with statistically significant differences( P < 0. 05). The FMA and MBI scores in the combined group were higher,while the TCM syndrome scores were lower than those in the control group,with statistically significant differences( P < 0. 05). The effective rate was 97. 92% in the combined group and 85. 42% in the control group,with a statistically significant difference( P < 0. 05). Conclusion: Time-selective balanced acupuncture based on the meridian-sinew theory combined with acupoint acupressure massage in the treatment of neck,shoulder,low back,and leg pain can significantly alleviate the clinical symptoms of patients,improve hemodynamics,promote blood circulation,reduce the release of pain-causing factors,thereby lessening the degree of pain and enhancing patients' motor function and daily living abilities.

    2026 03 v.46;No.411 [Abstract][OnlineView][Download 166K]

  • Clinical Study on Phlegm-Expelling Decoction Combined with Acupuncture at Four Points of Throat for Treating Post-Stroke Dysphagia

    LIU Jing;LIU Rui;ZHUANG Lanying;HU Liangen;Xinyu Hospital of Traditional Chinese Medicine;

    Objective: To observe the clinical efficacy of Phlegm-Expelling Decoction combined with acupuncture at four points of throat on post-stroke dysphagia. Methods: A total of 120 patients with post-stroke dysphagia treated at Xinyu Hospital of Traditional Chinese Medicine between March 2022 and March 2024 were selected and divided into the control group and the observation group using the random number table method,with 60 cases in each group. The control group received Phlegm-Expelling Decoction and traditional acupuncture treatment,while the observation group received additional acupuncture at four points of throat on the basis of the control group's therapy. The Water Swallowing Test score,Videofluoroscopic Swallowing Study( VFSS) score,rheoencephalography indicators,adverse reactions,and clinical efficacy were observed in the two groups. Results: Before treatment,there was no statistically significant difference in the Water Swallowing Test score or VFSS score between the two groups( P > 0. 05). After treatment,the observation group showed lower Water Swallowing Test and VFSS scores compared to the control group,with statistically significant differences( P < 0. 05). Before treatment,there were no statistically significant differences in the levels of BA,LVA,and RVA between the two groups( P > 0. 05). After treatment,the observation group exhibited higher levels of BA,LVA,and RVA than the control group,with statistically significant differences( P < 0. 05). The effective rate was 40. 00% in the control group and 81. 67% in the observation group,with the observation group showing a significantly higher effective rate,and the difference was statistically significant( P < 0. 05). The incidence of adverse reactions was 1. 67% in the observation group and 11. 67% in the control group,with the observation group demonstrating a significantly lower incidence of adverse reactions,and the difference was statistically significant( P < 0. 05). Conclusion: Phlegm-Expelling Decoction combined with acupuncture at four points of throat is much effective in treating post-stroke dysphagia,and can improve the patients' cerebral blood supply,and reduce adverse reactions.

    2026 03 v.46;No.411 [Abstract][OnlineView][Download 141K]

  • Clinical Study on the Treatment of Post-Ischemic Stroke Hemiplegia with Thunder-Fire Moxibustion Combined with Modified Decoction for Promoting Orifice Opening and Activating Blood

    ZHAO Miaoyin;SHAO Qingmin;PENG Junfeng;The Second Affiliated Hospital of Henan University of Chinese Medicine,Henan Province Hospital of Traditional Chinese Medicine;

    Objective: To observe the clinical efficacy of thunder-fire moxibustion combined with Modified Decoction for Promoting Orifice Opening and Activating Blood on post-ischemic stroke hemiplegia. Methods: A total of 116 patients with post-ischemic stroke hemiplegia were randomly divided into the control group and the study group according to the random number table method,with 58 cases in each group. All patients received conventional treatment. Then the control group was additionally treated with Modified Decoction for Promoting Orifice Opening and Activating Blood,while the study group received Thunder-Fire Moxibustion combined with Modified Decoction for Promoting Orifice Opening and Activating Blood. The changes in the modified Ashworth scale( MAS) grading,the simplified FuglMeyer assessment( FMA) score,the Berg balance scale( BBS) score,hemorheological indicators [including high-shear whole blood viscosity,plasma viscosity,and fibrinogen( FIB) ],and the integrated electromyography( IEMG) value of the affected limb' s surface muscles before and after treatment were observed in the two groups. Results: After treatment,the MAS grading was both improved compared with before treatment in the two groups. Furthermore,the MAS grading in the study group was superior to that in the control group,with statistically significant differences( P < 0. 05). The FMA score and BBS score of the affected limb in the study group were higher than those in the control group,with statistically significant differences( P < 0. 05). The high-shear whole blood viscosity,plasma viscosity,and FIB in the study group were lower than those in the control group,with statistically significant differences( P < 0. 05). the IEMG measurements of the affected-side brachioradialis,quadriceps femoris,and gastrocnemius muscles in the study group were all higher than those in the control group,with statistically significant differences( P < 0. 05). Conclusion: Thunder-fire moxibustion combined with Modified Decoction for Promoting Orifice Opening and Activating Blood can effectively reduce muscle tone and improve hemorheological indicators in patients with post-ischemic stroke hemiplegia,thereby promoting the recovery of motor function and balance function in the affected limb.

    2026 03 v.46;No.411 [Abstract][OnlineView][Download 156K]


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